Create a PKNCAdose object

Create a PKNCAdose object

PKNCAdose(data, ...)

# S3 method for default
PKNCAdose(data, ...)

# S3 method for tbl_df
PKNCAdose(data, ...)

# S3 method for data.frame
PKNCAdose(data, formula, route, rate, duration, time.nominal, exclude, ...)

Arguments

data	A data frame with time and the groups defined in formula.
...	Ignored.
formula	The formula defining the dose.amount~time|groups where time is the time of the dosing and dose.amount is the amount administered at that time (see Details).
route	Define the route of administration. The value may be either a column name from the data (checked first) or a character string of either "extravascular" or "intravascular" (checked second). If given as a column name, then every value of the column must be either "extravascular" or "intravascular".
rate, duration	(optional) for "intravascular" dosing, the rate or duration of dosing. If given as a character string, it is the name of a column from the data, and if given as a number, it is the value for all doses. Only one may be given, and if neither is given, then the dose is assumed to be a bolus (duration=0). If rate is given, then the dose amount must be given (the left hand side of the formula).
time.nominal	(optional) The name of the nominal time column (if the main time variable is actual time. The time.nominal is not used during calculations; it is available to assist with data summary and checking.
exclude	(optional) The name of a column with concentrations to exclude from calculations and summarization. If given, the column should have values of NA or "" for concentrations to include and non-empty text for concentrations to exclude.

Value

A PKNCAconc object that can be used for automated NCA.

Details

The formula for a PKNCAdose object can be given three ways: one-sided (missing left side), one-sided (missing right side), or two-sided. Each of the three ways can be given with or without groups. When given one-sided missing the left side, the left side can either be omitted or can be given as a period (.): ~time|treatment+subject and .~time|treatment+subject are identical, and dose-related NCA parameters will all be reported as not calculable (for example, clearance). When given one-sided missing the right side, the right side must be specified as a period (.): dose~.|treatment+subject, and only a single row may be given per group. When the right side is missing, PKNCA assumes that the same dose is given in every interval. When given as a two-sided formula

See also

Other PKNCA objects: PKNCAconc(), PKNCAdata(), PKNCAresults()