Calculate the (observed oral) clearance
pk.calc.cl(dose, auc)
| dose | the dose administered |
|---|---|
| auc | The area under the concentration-time curve. |
the numeric value of the total (CL) or observed oral clearance (CL/F)
cl is dose/auc.
If dose is the same length as the other inputs, then the
output will be the same length as all of the inputs; the function assumes
that you are calculating for multiple intervals simultaneously. If the
inputs other than dose are scalars and dose is a vector, then
the function assumes multiple doses were given in a single interval, and
the sum of the doses will be used for the calculation.
Gabrielsson J, Weiner D. "Section 2.5.1 Derivation of clearance." Pharmacokinetic & Pharmacodynamic Data Analysis: Concepts and Applications, 4th Edition. Stockholm, Sweden: Swedish Pharmaceutical Press, 2000. 86-7.