R/001-add.interval.col.R
get.interval.cols.RdGet the columns that can be used in an interval specification
get.interval.cols()
A list with named elements for each parameter. Each list element contains the parameter definition.
check.interval.specification() and the vignette
"Selection of Calculation Intervals"
Other Interval specifications:
add.interval.col(),
check.interval.deps(),
check.interval.specification(),
choose.auc.intervals(),
get.parameter.deps()
get.interval.cols() #> $start #> $start$FUN #> [1] NA #> #> $start$values #> function (x, ...) .Primitive("as.double") #> #> $start$desc #> [1] "Starting time of the interval" #> #> $start$formalsmap #> list() #> #> $start$depends #> NULL #> #> $start$datatype #> [1] "interval" #> #> #> $end #> $end$FUN #> [1] NA #> #> $end$values #> function (x, ...) .Primitive("as.double") #> #> $end$desc #> [1] "Ending time of the interval (potentially infinity)" #> #> $end$formalsmap #> list() #> #> $end$depends #> NULL #> #> $end$datatype #> [1] "interval" #> #> #> $auclast #> $auclast$FUN #> [1] "pk.calc.auc.last" #> #> $auclast$values #> [1] FALSE TRUE #> #> $auclast$desc #> [1] "The area under the concentration time curve from the beginning of the interval to the last concentration above the limit of quantification" #> #> $auclast$formalsmap #> list() #> #> $auclast$depends #> NULL #> #> $auclast$datatype #> [1] "interval" #> #> #> $aucall #> $aucall$FUN #> [1] "pk.calc.auc.all" #> #> $aucall$values #> [1] FALSE TRUE #> #> $aucall$desc #> [1] "The area under the concentration time curve from the beginning of the interval to the last concentration above the limit of quantification plus the triangle from that last concentration to 0 at the first concentration below the limit of quantification" #> #> $aucall$formalsmap #> list() #> #> $aucall$depends #> NULL #> #> $aucall$datatype #> [1] "interval" #> #> #> $aumclast #> $aumclast$FUN #> [1] "pk.calc.aumc.last" #> #> $aumclast$values #> [1] FALSE TRUE #> #> $aumclast$desc #> [1] "The area under the concentration time moment curve from the beginning of the interval to the last concentration above the limit of quantification" #> #> $aumclast$formalsmap #> list() #> #> $aumclast$depends #> NULL #> #> $aumclast$datatype #> [1] "interval" #> #> #> $aumcall #> $aumcall$FUN #> [1] "pk.calc.aumc.all" #> #> $aumcall$values #> [1] FALSE TRUE #> #> $aumcall$desc #> [1] "The area under the concentration time moment curve from the beginning of the interval to the last concentration above the limit of quantification plus the moment of the triangle from that last concentration to 0 at the first concentration below the limit of quantification" #> #> $aumcall$formalsmap #> list() #> #> $aumcall$depends #> NULL #> #> $aumcall$datatype #> [1] "interval" #> #> #> $aucint.last #> $aucint.last$FUN #> [1] "pk.calc.aucint.last" #> #> $aucint.last$values #> [1] FALSE TRUE #> #> $aucint.last$desc #> [1] "The area under the concentration time curve in the interval extrapolating from Tlast to infinity with zeros (matching AUClast)" #> #> $aucint.last$formalsmap #> $aucint.last$formalsmap$conc #> [1] "conc.group" #> #> $aucint.last$formalsmap$time #> [1] "time.group" #> #> $aucint.last$formalsmap$time.dose #> NULL #> #> #> $aucint.last$depends #> NULL #> #> $aucint.last$datatype #> [1] "interval" #> #> #> $aucint.last.dose #> $aucint.last.dose$FUN #> [1] "pk.calc.aucint.last" #> #> $aucint.last.dose$values #> [1] FALSE TRUE #> #> $aucint.last.dose$desc #> [1] "The area under the concentration time curve in the interval extrapolating from Tlast to infinity with zeros (matching AUClast)" #> #> $aucint.last.dose$formalsmap #> $aucint.last.dose$formalsmap$conc #> [1] "conc.group" #> #> $aucint.last.dose$formalsmap$time #> [1] "time.group" #> #> $aucint.last.dose$formalsmap$time.dose #> [1] "time.dose.group" #> #> #> $aucint.last.dose$depends #> NULL #> #> $aucint.last.dose$datatype #> [1] "interval" #> #> #> $aucint.all #> $aucint.all$FUN #> [1] "pk.calc.aucint.all" #> #> $aucint.all$values #> [1] FALSE TRUE #> #> $aucint.all$desc #> [1] "The area under the concentration time curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUCall)" #> #> $aucint.all$formalsmap #> $aucint.all$formalsmap$conc #> [1] "conc.group" #> #> $aucint.all$formalsmap$time #> [1] "time.group" #> #> $aucint.all$formalsmap$time.dose #> NULL #> #> #> $aucint.all$depends #> NULL #> #> $aucint.all$datatype #> [1] "interval" #> #> #> $aucint.all.dose #> $aucint.all.dose$FUN #> [1] "pk.calc.aucint.all" #> #> $aucint.all.dose$values #> [1] FALSE TRUE #> #> $aucint.all.dose$desc #> [1] "The area under the concentration time curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUCall)" #> #> $aucint.all.dose$formalsmap #> $aucint.all.dose$formalsmap$conc #> [1] "conc.group" #> #> $aucint.all.dose$formalsmap$time #> [1] "time.group" #> #> $aucint.all.dose$formalsmap$time.dose #> [1] "time.dose.group" #> #> #> $aucint.all.dose$depends #> NULL #> #> $aucint.all.dose$datatype #> [1] "interval" #> #> #> $auclast.dn #> $auclast.dn$FUN #> [1] "pk.calc.dn" #> #> $auclast.dn$values #> [1] FALSE TRUE #> #> $auclast.dn$desc #> [1] "Dose normalized auclast" #> #> $auclast.dn$formalsmap #> $auclast.dn$formalsmap$parameter #> [1] "auclast" #> #> #> $auclast.dn$depends #> [1] "auclast" #> #> $auclast.dn$datatype #> [1] "interval" #> #> #> $aucall.dn #> $aucall.dn$FUN #> [1] "pk.calc.dn" #> #> $aucall.dn$values #> [1] FALSE TRUE #> #> $aucall.dn$desc #> [1] "Dose normalized aucall" #> #> $aucall.dn$formalsmap #> $aucall.dn$formalsmap$parameter #> [1] "aucall" #> #> #> $aucall.dn$depends #> [1] "aucall" #> #> $aucall.dn$datatype #> [1] "interval" #> #> #> $aumclast.dn #> $aumclast.dn$FUN #> [1] "pk.calc.dn" #> #> $aumclast.dn$values #> [1] FALSE TRUE #> #> $aumclast.dn$desc #> [1] "Dose normalized aumclast" #> #> $aumclast.dn$formalsmap #> $aumclast.dn$formalsmap$parameter #> [1] "aumclast" #> #> #> $aumclast.dn$depends #> [1] "aumclast" #> #> $aumclast.dn$datatype #> [1] "interval" #> #> #> $aumcall.dn #> $aumcall.dn$FUN #> [1] "pk.calc.dn" #> #> $aumcall.dn$values #> [1] FALSE TRUE #> #> $aumcall.dn$desc #> [1] "Dose normalized aumcall" #> #> $aumcall.dn$formalsmap #> $aumcall.dn$formalsmap$parameter #> [1] "aumcall" #> #> #> $aumcall.dn$depends #> [1] "aumcall" #> #> $aumcall.dn$datatype #> [1] "interval" #> #> #> $cmax #> $cmax$FUN #> [1] "pk.calc.cmax" #> #> $cmax$values #> [1] FALSE TRUE #> #> $cmax$desc #> [1] "Maximum observed concentration" #> #> $cmax$formalsmap #> list() #> #> $cmax$depends #> NULL #> #> $cmax$datatype #> [1] "interval" #> #> #> $cmin #> $cmin$FUN #> [1] "pk.calc.cmin" #> #> $cmin$values #> [1] FALSE TRUE #> #> $cmin$desc #> [1] "Minimum observed concentration" #> #> $cmin$formalsmap #> list() #> #> $cmin$depends #> NULL #> #> $cmin$datatype #> [1] "interval" #> #> #> $tmax #> $tmax$FUN #> [1] "pk.calc.tmax" #> #> $tmax$values #> [1] FALSE TRUE #> #> $tmax$desc #> [1] "Time of the maximum observed concentration" #> #> $tmax$formalsmap #> list() #> #> $tmax$depends #> NULL #> #> $tmax$datatype #> [1] "interval" #> #> #> $tlast #> $tlast$FUN #> [1] "pk.calc.tlast" #> #> $tlast$values #> [1] FALSE TRUE #> #> $tlast$desc #> [1] "Time of the last concentration observed above the limit of quantification" #> #> $tlast$formalsmap #> list() #> #> $tlast$depends #> NULL #> #> $tlast$datatype #> [1] "interval" #> #> #> $tfirst #> $tfirst$FUN #> [1] "pk.calc.tfirst" #> #> $tfirst$values #> [1] FALSE TRUE #> #> $tfirst$desc #> [1] "Time of the first concentration above the limit of quantification" #> #> $tfirst$formalsmap #> list() #> #> $tfirst$depends #> NULL #> #> $tfirst$datatype #> [1] "interval" #> #> #> $clast.obs #> $clast.obs$FUN #> [1] "pk.calc.clast.obs" #> #> $clast.obs$values #> [1] FALSE TRUE #> #> $clast.obs$desc #> [1] "The last concentration observed above the limit of quantification" #> #> $clast.obs$formalsmap #> list() #> #> $clast.obs$depends #> NULL #> #> $clast.obs$datatype #> [1] "interval" #> #> #> $cl.last #> $cl.last$FUN #> [1] "pk.calc.cl" #> #> $cl.last$values #> [1] FALSE TRUE #> #> $cl.last$desc #> [1] "Clearance or observed oral clearance calculated to Clast" #> #> $cl.last$formalsmap #> $cl.last$formalsmap$auc #> [1] "auclast" #> #> #> $cl.last$depends #> [1] "auclast" #> #> $cl.last$datatype #> [1] "interval" #> #> #> $cl.all #> $cl.all$FUN #> [1] "pk.calc.cl" #> #> $cl.all$values #> [1] FALSE TRUE #> #> $cl.all$desc #> [1] "Clearance or observed oral clearance calculated with AUCall" #> #> $cl.all$formalsmap #> $cl.all$formalsmap$auc #> [1] "aucall" #> #> #> $cl.all$depends #> [1] "aucall" #> #> $cl.all$datatype #> [1] "interval" #> #> #> $f #> $f$FUN #> [1] "pk.calc.f" #> #> $f$values #> [1] FALSE TRUE #> #> $f$desc #> [1] "Bioavailability or relative bioavailability" #> #> $f$formalsmap #> list() #> #> $f$depends #> NULL #> #> $f$datatype #> [1] "interval" #> #> #> $mrt.last #> $mrt.last$FUN #> [1] "pk.calc.mrt" #> #> $mrt.last$values #> [1] FALSE TRUE #> #> $mrt.last$desc #> [1] "The mean residence time to the last observed concentration above the LOQ" #> #> $mrt.last$formalsmap #> $mrt.last$formalsmap$auc #> [1] "auclast" #> #> $mrt.last$formalsmap$aumc #> [1] "aumclast" #> #> #> $mrt.last$depends #> $mrt.last$depends[[1]] #> [1] "auclast" #> #> $mrt.last$depends[[2]] #> [1] "aumclast" #> #> #> $mrt.last$datatype #> [1] "interval" #> #> #> $mrt.iv.last #> $mrt.iv.last$FUN #> [1] "pk.calc.mrt.iv" #> #> $mrt.iv.last$values #> [1] FALSE TRUE #> #> $mrt.iv.last$desc #> [1] "The mean residence time to the last observed concentration above the LOQ correcting for dosing duration" #> #> $mrt.iv.last$formalsmap #> $mrt.iv.last$formalsmap$auc #> [1] "auclast" #> #> $mrt.iv.last$formalsmap$aumc #> [1] "aumclast" #> #> #> $mrt.iv.last$depends #> $mrt.iv.last$depends[[1]] #> [1] "auclast" #> #> $mrt.iv.last$depends[[2]] #> [1] "aumclast" #> #> #> $mrt.iv.last$datatype #> [1] "interval" #> #> #> $vss.last #> $vss.last$FUN #> [1] "pk.calc.vss" #> #> $vss.last$values #> [1] FALSE TRUE #> #> $vss.last$desc #> [1] "The steady-state volume of distribution calculating through Tlast" #> #> $vss.last$formalsmap #> $vss.last$formalsmap$cl #> [1] "cl.last" #> #> $vss.last$formalsmap$mrt #> [1] "mrt.last" #> #> #> $vss.last$depends #> [1] "cl.last" "mrt.last" #> #> $vss.last$datatype #> [1] "interval" #> #> #> $vss.iv.last #> $vss.iv.last$FUN #> [1] "pk.calc.vss" #> #> $vss.iv.last$values #> [1] FALSE TRUE #> #> $vss.iv.last$desc #> [1] "The steady-state volume of distribution with intravenous infusion calculating through Tlast" #> #> $vss.iv.last$formalsmap #> $vss.iv.last$formalsmap$cl #> [1] "cl.last" #> #> $vss.iv.last$formalsmap$mrt #> [1] "mrt.iv.last" #> #> #> $vss.iv.last$depends #> [1] "cl.last" "mrt.iv.last" #> #> $vss.iv.last$datatype #> [1] "interval" #> #> #> $cav #> $cav$FUN #> [1] "pk.calc.cav" #> #> $cav$values #> [1] FALSE TRUE #> #> $cav$desc #> [1] "The average concentration during an interval" #> #> $cav$formalsmap #> list() #> #> $cav$depends #> [1] "auclast" #> #> $cav$datatype #> [1] "interval" #> #> #> $ctrough #> $ctrough$FUN #> [1] "pk.calc.ctrough" #> #> $ctrough$values #> [1] FALSE TRUE #> #> $ctrough$desc #> [1] "The trough (predose) concentration" #> #> $ctrough$formalsmap #> list() #> #> $ctrough$depends #> NULL #> #> $ctrough$datatype #> [1] "interval" #> #> #> $ptr #> $ptr$FUN #> [1] "pk.calc.ptr" #> #> $ptr$values #> [1] FALSE TRUE #> #> $ptr$desc #> [1] "Peak-to-Trough ratio (fraction)" #> #> $ptr$formalsmap #> list() #> #> $ptr$depends #> [1] "cmax" "ctrough" #> #> $ptr$datatype #> [1] "interval" #> #> #> $tlag #> $tlag$FUN #> [1] "pk.calc.tlag" #> #> $tlag$values #> [1] FALSE TRUE #> #> $tlag$desc #> [1] "Lag time" #> #> $tlag$formalsmap #> list() #> #> $tlag$depends #> NULL #> #> $tlag$datatype #> [1] "interval" #> #> #> $deg.fluc #> $deg.fluc$FUN #> [1] "pk.calc.deg.fluc" #> #> $deg.fluc$values #> [1] FALSE TRUE #> #> $deg.fluc$desc #> [1] "Degree of fluctuation" #> #> $deg.fluc$formalsmap #> list() #> #> $deg.fluc$depends #> [1] "cmax" "cmin" "cav" #> #> $deg.fluc$datatype #> [1] "interval" #> #> #> $swing #> $swing$FUN #> [1] "pk.calc.swing" #> #> $swing$values #> [1] FALSE TRUE #> #> $swing$desc #> [1] "Swing relative to Cmin" #> #> $swing$formalsmap #> list() #> #> $swing$depends #> [1] "cmax" "cmin" #> #> $swing$datatype #> [1] "interval" #> #> #> $ceoi #> $ceoi$FUN #> [1] "pk.calc.ceoi" #> #> $ceoi$values #> [1] FALSE TRUE #> #> $ceoi$desc #> [1] "Concentration at the end of infusion" #> #> $ceoi$formalsmap #> list() #> #> $ceoi$depends #> NULL #> #> $ceoi$datatype #> [1] "interval" #> #> #> $ae #> $ae$FUN #> [1] "pk.calc.ae" #> #> $ae$values #> [1] FALSE TRUE #> #> $ae$desc #> [1] "The amount excreted (typically into urine or feces)" #> #> $ae$formalsmap #> list() #> #> $ae$depends #> NULL #> #> $ae$datatype #> [1] "interval" #> #> #> $clr.last #> $clr.last$FUN #> [1] "pk.calc.clr" #> #> $clr.last$values #> [1] FALSE TRUE #> #> $clr.last$desc #> [1] "The renal clearance calculated using AUClast" #> #> $clr.last$formalsmap #> $clr.last$formalsmap$auc #> [1] "auclast" #> #> #> $clr.last$depends #> NULL #> #> $clr.last$datatype #> [1] "interval" #> #> #> $clr.obs #> $clr.obs$FUN #> [1] "pk.calc.clr" #> #> $clr.obs$values #> [1] FALSE TRUE #> #> $clr.obs$desc #> [1] "The renal clearance calculated using AUCinf,obs" #> #> $clr.obs$formalsmap #> $clr.obs$formalsmap$auc #> [1] "aucinf.obs" #> #> #> $clr.obs$depends #> NULL #> #> $clr.obs$datatype #> [1] "interval" #> #> #> $clr.pred #> $clr.pred$FUN #> [1] "pk.calc.clr" #> #> $clr.pred$values #> [1] FALSE TRUE #> #> $clr.pred$desc #> [1] "The renal clearance calculated using AUCinf,pred" #> #> $clr.pred$formalsmap #> $clr.pred$formalsmap$auc #> [1] "aucinf.pred" #> #> #> $clr.pred$depends #> NULL #> #> $clr.pred$datatype #> [1] "interval" #> #> #> $fe #> $fe$FUN #> [1] "pk.calc.fe" #> #> $fe$values #> [1] FALSE TRUE #> #> $fe$desc #> [1] "The fraction of the dose excreted" #> #> $fe$formalsmap #> list() #> #> $fe$depends #> NULL #> #> $fe$datatype #> [1] "interval" #> #> #> $time_above #> $time_above$FUN #> [1] "pk.calc.time_above" #> #> $time_above$values #> [1] FALSE TRUE #> #> $time_above$desc #> [1] "Time above a given concentration" #> #> $time_above$formalsmap #> list() #> #> $time_above$depends #> NULL #> #> $time_above$datatype #> [1] "interval" #> #> #> $half.life #> $half.life$FUN #> [1] "pk.calc.half.life" #> #> $half.life$values #> [1] FALSE TRUE #> #> $half.life$desc #> [1] "The (terminal) half-life" #> #> $half.life$formalsmap #> list() #> #> $half.life$depends #> [1] "tmax" "tlast" #> #> $half.life$datatype #> [1] "interval" #> #> #> $r.squared #> $r.squared$FUN #> [1] NA #> #> $r.squared$values #> [1] FALSE TRUE #> #> $r.squared$desc #> [1] "The r^2 value of the half-life calculation" #> #> $r.squared$formalsmap #> list() #> #> $r.squared$depends #> [1] "half.life" #> #> $r.squared$datatype #> [1] "interval" #> #> #> $adj.r.squared #> $adj.r.squared$FUN #> [1] NA #> #> $adj.r.squared$values #> [1] FALSE TRUE #> #> $adj.r.squared$desc #> [1] "The adjusted r^2 value of the half-life calculation" #> #> $adj.r.squared$formalsmap #> list() #> #> $adj.r.squared$depends #> [1] "half.life" #> #> $adj.r.squared$datatype #> [1] "interval" #> #> #> $lambda.z #> $lambda.z$FUN #> [1] NA #> #> $lambda.z$values #> [1] FALSE TRUE #> #> $lambda.z$desc #> [1] "The elimination rate of the terminal half-life" #> #> $lambda.z$formalsmap #> list() #> #> $lambda.z$depends #> [1] "half.life" #> #> $lambda.z$datatype #> [1] "interval" #> #> #> $lambda.z.time.first #> $lambda.z.time.first$FUN #> [1] NA #> #> $lambda.z.time.first$values #> [1] FALSE TRUE #> #> $lambda.z.time.first$desc #> [1] "The first time point used for the calculation of half-life" #> #> $lambda.z.time.first$formalsmap #> list() #> #> $lambda.z.time.first$depends #> [1] "half.life" #> #> $lambda.z.time.first$datatype #> [1] "interval" #> #> #> $lambda.z.n.points #> $lambda.z.n.points$FUN #> [1] NA #> #> $lambda.z.n.points$values #> [1] FALSE TRUE #> #> $lambda.z.n.points$desc #> [1] "The number of points used for the calculation of half-life" #> #> $lambda.z.n.points$formalsmap #> list() #> #> $lambda.z.n.points$depends #> [1] "half.life" #> #> $lambda.z.n.points$datatype #> [1] "interval" #> #> #> $clast.pred #> $clast.pred$FUN #> [1] NA #> #> $clast.pred$values #> [1] FALSE TRUE #> #> $clast.pred$desc #> [1] "The concentration at Tlast as predicted by the half-life" #> #> $clast.pred$formalsmap #> list() #> #> $clast.pred$depends #> [1] "half.life" #> #> $clast.pred$datatype #> [1] "interval" #> #> #> $span.ratio #> $span.ratio$FUN #> [1] NA #> #> $span.ratio$values #> [1] FALSE TRUE #> #> $span.ratio$desc #> [1] "The ratio of the half-life to the duration used for half-life calculation" #> #> $span.ratio$formalsmap #> list() #> #> $span.ratio$depends #> [1] "half.life" #> #> $span.ratio$datatype #> [1] "interval" #> #> #> $cmax.dn #> $cmax.dn$FUN #> [1] "pk.calc.dn" #> #> $cmax.dn$values #> [1] FALSE TRUE #> #> $cmax.dn$desc #> [1] "Dose normalized cmax" #> #> $cmax.dn$formalsmap #> $cmax.dn$formalsmap$parameter #> [1] "cmax" #> #> #> $cmax.dn$depends #> [1] "cmax" #> #> $cmax.dn$datatype #> [1] "interval" #> #> #> $cmin.dn #> $cmin.dn$FUN #> [1] "pk.calc.dn" #> #> $cmin.dn$values #> [1] FALSE TRUE #> #> $cmin.dn$desc #> [1] "Dose normalized cmin" #> #> $cmin.dn$formalsmap #> $cmin.dn$formalsmap$parameter #> [1] "cmin" #> #> #> $cmin.dn$depends #> [1] "cmin" #> #> $cmin.dn$datatype #> [1] "interval" #> #> #> $clast.obs.dn #> $clast.obs.dn$FUN #> [1] "pk.calc.dn" #> #> $clast.obs.dn$values #> [1] FALSE TRUE #> #> $clast.obs.dn$desc #> [1] "Dose normalized clast.obs" #> #> $clast.obs.dn$formalsmap #> $clast.obs.dn$formalsmap$parameter #> [1] "clast.obs" #> #> #> $clast.obs.dn$depends #> [1] "clast.obs" #> #> $clast.obs.dn$datatype #> [1] "interval" #> #> #> $clast.pred.dn #> $clast.pred.dn$FUN #> [1] "pk.calc.dn" #> #> $clast.pred.dn$values #> [1] FALSE TRUE #> #> $clast.pred.dn$desc #> [1] "Dose normalized clast.pred" #> #> $clast.pred.dn$formalsmap #> $clast.pred.dn$formalsmap$parameter #> [1] "clast.pred" #> #> #> $clast.pred.dn$depends #> [1] "clast.pred" #> #> $clast.pred.dn$datatype #> [1] "interval" #> #> #> $cav.dn #> $cav.dn$FUN #> [1] "pk.calc.dn" #> #> $cav.dn$values #> [1] FALSE TRUE #> #> $cav.dn$desc #> [1] "Dose normalized cav" #> #> $cav.dn$formalsmap #> $cav.dn$formalsmap$parameter #> [1] "cav" #> #> #> $cav.dn$depends #> [1] "cav" #> #> $cav.dn$datatype #> [1] "interval" #> #> #> $ctrough.dn #> $ctrough.dn$FUN #> [1] "pk.calc.dn" #> #> $ctrough.dn$values #> [1] FALSE TRUE #> #> $ctrough.dn$desc #> [1] "Dose normalized ctrough" #> #> $ctrough.dn$formalsmap #> $ctrough.dn$formalsmap$parameter #> [1] "ctrough" #> #> #> $ctrough.dn$depends #> [1] "ctrough" #> #> $ctrough.dn$datatype #> [1] "interval" #> #> #> $thalf.eff.last #> $thalf.eff.last$FUN #> [1] "pk.calc.thalf.eff" #> #> $thalf.eff.last$values #> [1] FALSE TRUE #> #> $thalf.eff.last$desc #> [1] "The effective half-life (as determined from the MRTlast)" #> #> $thalf.eff.last$formalsmap #> $thalf.eff.last$formalsmap$mrt #> [1] "mrt.last" #> #> #> $thalf.eff.last$depends #> [1] "mrt.last" #> #> $thalf.eff.last$datatype #> [1] "interval" #> #> #> $thalf.eff.iv.last #> $thalf.eff.iv.last$FUN #> [1] "pk.calc.thalf.eff" #> #> $thalf.eff.iv.last$values #> [1] FALSE TRUE #> #> $thalf.eff.iv.last$desc #> [1] "The effective half-life (as determined from the intravenous MRTlast)" #> #> $thalf.eff.iv.last$formalsmap #> $thalf.eff.iv.last$formalsmap$mrt #> [1] "mrt.iv.last" #> #> #> $thalf.eff.iv.last$depends #> [1] "mrt.iv.last" #> #> $thalf.eff.iv.last$datatype #> [1] "interval" #> #> #> $kel.last #> $kel.last$FUN #> [1] "pk.calc.kel" #> #> $kel.last$values #> [1] FALSE TRUE #> #> $kel.last$desc #> [1] "Elimination rate (as calculated from the MRT using AUClast)" #> #> $kel.last$formalsmap #> $kel.last$formalsmap$mrt #> [1] "mrt.last" #> #> #> $kel.last$depends #> [1] "mrt.last" #> #> $kel.last$datatype #> [1] "interval" #> #> #> $kel.iv.last #> $kel.iv.last$FUN #> [1] "pk.calc.kel" #> #> $kel.iv.last$values #> [1] FALSE TRUE #> #> $kel.iv.last$desc #> [1] "Elimination rate (as calculated from the intravenous MRTlast)" #> #> $kel.iv.last$formalsmap #> $kel.iv.last$formalsmap$mrt #> [1] "mrt.iv.last" #> #> #> $kel.iv.last$depends #> [1] "mrt.iv.last" #> #> $kel.iv.last$datatype #> [1] "interval" #> #> #> $aucinf.obs #> $aucinf.obs$FUN #> [1] "pk.calc.auc.inf.obs" #> #> $aucinf.obs$values #> [1] FALSE TRUE #> #> $aucinf.obs$desc #> [1] "The area under the concentration time curve from the beginning of the interval to infinity with extrapolation to infinity from the observed Clast" #> #> $aucinf.obs$formalsmap #> list() #> #> $aucinf.obs$depends #> [1] "lambda.z" "clast.obs" #> #> $aucinf.obs$datatype #> [1] "interval" #> #> #> $aucinf.pred #> $aucinf.pred$FUN #> [1] "pk.calc.auc.inf.pred" #> #> $aucinf.pred$values #> [1] FALSE TRUE #> #> $aucinf.pred$desc #> [1] "The area under the concentration time curve from the beginning of the interval to infinity with extrapolation to infinity from the predicted Clast" #> #> $aucinf.pred$formalsmap #> list() #> #> $aucinf.pred$depends #> [1] "lambda.z" "clast.pred" #> #> $aucinf.pred$datatype #> [1] "interval" #> #> #> $aumcinf.obs #> $aumcinf.obs$FUN #> [1] "pk.calc.aumc.inf.obs" #> #> $aumcinf.obs$values #> [1] FALSE TRUE #> #> $aumcinf.obs$desc #> [1] "The area under the concentration time moment curve from the beginning of the interval to infinity with extrapolation to infinity from the observed Clast" #> #> $aumcinf.obs$formalsmap #> list() #> #> $aumcinf.obs$depends #> [1] "lambda.z" "clast.obs" #> #> $aumcinf.obs$datatype #> [1] "interval" #> #> #> $aumcinf.pred #> $aumcinf.pred$FUN #> [1] "pk.calc.aumc.inf.pred" #> #> $aumcinf.pred$values #> [1] FALSE TRUE #> #> $aumcinf.pred$desc #> [1] "The area under the concentration time moment curve from the beginning of the interval to infinity with extrapolation to infinity from the predicted Clast" #> #> $aumcinf.pred$formalsmap #> list() #> #> $aumcinf.pred$depends #> [1] "lambda.z" "clast.pred" #> #> $aumcinf.pred$datatype #> [1] "interval" #> #> #> $aucint.inf.obs #> $aucint.inf.obs$FUN #> [1] "pk.calc.aucint.inf.obs" #> #> $aucint.inf.obs$values #> [1] FALSE TRUE #> #> $aucint.inf.obs$desc #> [1] "The area under the concentration time curve in the interval extrapolating from Tlast to infinity with zeros (matching AUClast)" #> #> $aucint.inf.obs$formalsmap #> $aucint.inf.obs$formalsmap$conc #> [1] "conc.group" #> #> $aucint.inf.obs$formalsmap$time #> [1] "time.group" #> #> $aucint.inf.obs$formalsmap$time.dose #> NULL #> #> #> $aucint.inf.obs$depends #> [1] "lambda.z" "clast.obs" #> #> $aucint.inf.obs$datatype #> [1] "interval" #> #> #> $aucint.inf.obs.dose #> $aucint.inf.obs.dose$FUN #> [1] "pk.calc.aucint.inf.obs" #> #> $aucint.inf.obs.dose$values #> [1] FALSE TRUE #> #> $aucint.inf.obs.dose$desc #> [1] "The area under the concentration time curve in the interval extrapolating from Tlast to infinity with zeros (matching AUClast)" #> #> $aucint.inf.obs.dose$formalsmap #> $aucint.inf.obs.dose$formalsmap$conc #> [1] "conc.group" #> #> $aucint.inf.obs.dose$formalsmap$time #> [1] "time.group" #> #> $aucint.inf.obs.dose$formalsmap$time.dose #> [1] "time.dose.group" #> #> #> $aucint.inf.obs.dose$depends #> [1] "lambda.z" "clast.obs" #> #> $aucint.inf.obs.dose$datatype #> [1] "interval" #> #> #> $aucint.inf.pred #> $aucint.inf.pred$FUN #> [1] "pk.calc.aucint.inf.pred" #> #> $aucint.inf.pred$values #> [1] FALSE TRUE #> #> $aucint.inf.pred$desc #> [1] "The area under the concentration time curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUCall)" #> #> $aucint.inf.pred$formalsmap #> $aucint.inf.pred$formalsmap$conc #> [1] "conc.group" #> #> $aucint.inf.pred$formalsmap$time #> [1] "time.group" #> #> $aucint.inf.pred$formalsmap$time.dose #> NULL #> #> #> $aucint.inf.pred$depends #> [1] "lambda.z" "clast.pred" #> #> $aucint.inf.pred$datatype #> [1] "interval" #> #> #> $aucint.inf.pred.dose #> $aucint.inf.pred.dose$FUN #> [1] "pk.calc.aucint.inf.pred" #> #> $aucint.inf.pred.dose$values #> [1] FALSE TRUE #> #> $aucint.inf.pred.dose$desc #> [1] "The area under the concentration time curve in the interval extrapolating from Tlast to infinity with the triangle from Tlast to the next point and zero thereafter (matching AUCall)" #> #> $aucint.inf.pred.dose$formalsmap #> $aucint.inf.pred.dose$formalsmap$conc #> [1] "conc.group" #> #> $aucint.inf.pred.dose$formalsmap$time #> [1] "time.group" #> #> $aucint.inf.pred.dose$formalsmap$time.dose #> [1] "time.dose.group" #> #> #> $aucint.inf.pred.dose$depends #> [1] "lambda.z" "clast.pred" #> #> $aucint.inf.pred.dose$datatype #> [1] "interval" #> #> #> $aucinf.obs.dn #> $aucinf.obs.dn$FUN #> [1] "pk.calc.dn" #> #> $aucinf.obs.dn$values #> [1] FALSE TRUE #> #> $aucinf.obs.dn$desc #> [1] "Dose normalized aucinf.obs" #> #> $aucinf.obs.dn$formalsmap #> $aucinf.obs.dn$formalsmap$parameter #> [1] "aucinf.obs" #> #> #> $aucinf.obs.dn$depends #> [1] "aucinf.obs" #> #> $aucinf.obs.dn$datatype #> [1] "interval" #> #> #> $aucinf.pred.dn #> $aucinf.pred.dn$FUN #> [1] "pk.calc.dn" #> #> $aucinf.pred.dn$values #> [1] FALSE TRUE #> #> $aucinf.pred.dn$desc #> [1] "Dose normalized aucinf.pred" #> #> $aucinf.pred.dn$formalsmap #> $aucinf.pred.dn$formalsmap$parameter #> [1] "aucinf.pred" #> #> #> $aucinf.pred.dn$depends #> [1] "aucinf.pred" #> #> $aucinf.pred.dn$datatype #> [1] "interval" #> #> #> $aumcinf.obs.dn #> $aumcinf.obs.dn$FUN #> [1] "pk.calc.dn" #> #> $aumcinf.obs.dn$values #> [1] FALSE TRUE #> #> $aumcinf.obs.dn$desc #> [1] "Dose normalized aumcinf.obs" #> #> $aumcinf.obs.dn$formalsmap #> $aumcinf.obs.dn$formalsmap$parameter #> [1] "aumcinf.obs" #> #> #> $aumcinf.obs.dn$depends #> [1] "aumcinf.obs" #> #> $aumcinf.obs.dn$datatype #> [1] "interval" #> #> #> $aumcinf.pred.dn #> $aumcinf.pred.dn$FUN #> [1] "pk.calc.dn" #> #> $aumcinf.pred.dn$values #> [1] FALSE TRUE #> #> $aumcinf.pred.dn$desc #> [1] "Dose normalized aumcinf.pred" #> #> $aumcinf.pred.dn$formalsmap #> $aumcinf.pred.dn$formalsmap$parameter #> [1] "aumcinf.pred" #> #> #> $aumcinf.pred.dn$depends #> [1] "aumcinf.pred" #> #> $aumcinf.pred.dn$datatype #> [1] "interval" #> #> #> $aucpext.obs #> $aucpext.obs$FUN #> [1] "pk.calc.aucpext" #> #> $aucpext.obs$values #> [1] FALSE TRUE #> #> $aucpext.obs$desc #> [1] "Percent of the AUCinf that is extrapolated after Tlast calculated from the observed Clast" #> #> $aucpext.obs$formalsmap #> $aucpext.obs$formalsmap$aucinf #> [1] "aucinf.obs" #> #> #> $aucpext.obs$depends #> [1] "auclast" "aucinf.obs" #> #> $aucpext.obs$datatype #> [1] "interval" #> #> #> $aucpext.pred #> $aucpext.pred$FUN #> [1] "pk.calc.aucpext" #> #> $aucpext.pred$values #> [1] FALSE TRUE #> #> $aucpext.pred$desc #> [1] "Percent of the AUCinf that is extrapolated after Tlast calculated from the predicted Clast" #> #> $aucpext.pred$formalsmap #> $aucpext.pred$formalsmap$aucinf #> [1] "aucinf.pred" #> #> #> $aucpext.pred$depends #> [1] "auclast" "aucinf.pred" #> #> $aucpext.pred$datatype #> [1] "interval" #> #> #> $cl.obs #> $cl.obs$FUN #> [1] "pk.calc.cl" #> #> $cl.obs$values #> [1] FALSE TRUE #> #> $cl.obs$desc #> [1] "Clearance or observed oral clearance calculated with observed Clast" #> #> $cl.obs$formalsmap #> $cl.obs$formalsmap$auc #> [1] "aucinf.obs" #> #> #> $cl.obs$depends #> [1] "aucinf.obs" #> #> $cl.obs$datatype #> [1] "interval" #> #> #> $cl.pred #> $cl.pred$FUN #> [1] "pk.calc.cl" #> #> $cl.pred$values #> [1] FALSE TRUE #> #> $cl.pred$desc #> [1] "Clearance or observed oral clearance calculated with predicted Clast" #> #> $cl.pred$formalsmap #> $cl.pred$formalsmap$auc #> [1] "aucinf.pred" #> #> #> $cl.pred$depends #> $cl.pred$depends[[1]] #> [1] "aucinf.pred" #> #> #> $cl.pred$datatype #> [1] "interval" #> #> #> $mrt.obs #> $mrt.obs$FUN #> [1] "pk.calc.mrt" #> #> $mrt.obs$values #> [1] FALSE TRUE #> #> $mrt.obs$desc #> [1] "The mean residence time to infinity using observed Clast" #> #> $mrt.obs$formalsmap #> $mrt.obs$formalsmap$auc #> [1] "aucinf.obs" #> #> $mrt.obs$formalsmap$aumc #> [1] "aumcinf.obs" #> #> #> $mrt.obs$depends #> [1] "aucinf.obs" "aumcinf.obs" #> #> $mrt.obs$datatype #> [1] "interval" #> #> #> $mrt.pred #> $mrt.pred$FUN #> [1] "pk.calc.mrt" #> #> $mrt.pred$values #> [1] FALSE TRUE #> #> $mrt.pred$desc #> [1] "The mean residence time to infinity using predicted Clast" #> #> $mrt.pred$formalsmap #> $mrt.pred$formalsmap$auc #> [1] "aucinf.pred" #> #> $mrt.pred$formalsmap$aumc #> [1] "aumcinf.pred" #> #> #> $mrt.pred$depends #> [1] "aucinf.pred" "aumcinf.pred" #> #> $mrt.pred$datatype #> [1] "interval" #> #> #> $mrt.iv.obs #> $mrt.iv.obs$FUN #> [1] "pk.calc.mrt.iv" #> #> $mrt.iv.obs$values #> [1] FALSE TRUE #> #> $mrt.iv.obs$desc #> [1] "The mean residence time to infinity using observed Clast correcting for dosing duration" #> #> $mrt.iv.obs$formalsmap #> $mrt.iv.obs$formalsmap$auc #> [1] "aucinf.obs" #> #> $mrt.iv.obs$formalsmap$aumc #> [1] "aumcinf.obs" #> #> #> $mrt.iv.obs$depends #> [1] "aucinf.obs" "aumcinf.obs" #> #> $mrt.iv.obs$datatype #> [1] "interval" #> #> #> $mrt.iv.pred #> $mrt.iv.pred$FUN #> [1] "pk.calc.mrt.iv" #> #> $mrt.iv.pred$values #> [1] FALSE TRUE #> #> $mrt.iv.pred$desc #> [1] "The mean residence time to infinity using predicted Clast correcting for dosing duration" #> #> $mrt.iv.pred$formalsmap #> $mrt.iv.pred$formalsmap$auc #> [1] "aucinf.pred" #> #> $mrt.iv.pred$formalsmap$aumc #> [1] "aumcinf.pred" #> #> #> $mrt.iv.pred$depends #> [1] "aucinf.pred" "aumcinf.pred" #> #> $mrt.iv.pred$datatype #> [1] "interval" #> #> #> $mrt.md.obs #> $mrt.md.obs$FUN #> [1] "pk.calc.mrt.md" #> #> $mrt.md.obs$values #> [1] FALSE TRUE #> #> $mrt.md.obs$desc #> [1] "The mean residence time with multiple dosing and nonlinear kinetics using observed Clast" #> #> $mrt.md.obs$formalsmap #> $mrt.md.obs$formalsmap$auctau #> [1] "auclast" #> #> $mrt.md.obs$formalsmap$aumctau #> [1] "aumclast" #> #> $mrt.md.obs$formalsmap$aucinf #> [1] "aucinf.obs" #> #> #> $mrt.md.obs$depends #> [1] "auclast" "aumclast" "aucinf.obs" #> #> $mrt.md.obs$datatype #> [1] "interval" #> #> #> $mrt.md.pred #> $mrt.md.pred$FUN #> [1] "pk.calc.mrt.md" #> #> $mrt.md.pred$values #> [1] FALSE TRUE #> #> $mrt.md.pred$desc #> [1] "The mean residence time with multiple dosing and nonlinear kinetics using predicted Clast" #> #> $mrt.md.pred$formalsmap #> $mrt.md.pred$formalsmap$auctau #> [1] "auclast" #> #> $mrt.md.pred$formalsmap$aumctau #> [1] "aumclast" #> #> $mrt.md.pred$formalsmap$aucinf #> [1] "aucinf.pred" #> #> #> $mrt.md.pred$depends #> [1] "auclast" "aumclast" "aucinf.pred" #> #> $mrt.md.pred$datatype #> [1] "interval" #> #> #> $vz.obs #> $vz.obs$FUN #> [1] "pk.calc.vz" #> #> $vz.obs$values #> [1] FALSE TRUE #> #> $vz.obs$desc #> [1] "The terminal volume of distribution using observed Clast" #> #> $vz.obs$formalsmap #> $vz.obs$formalsmap$cl #> [1] "cl.obs" #> #> #> $vz.obs$depends #> [1] "cl.obs" "lambda.z" #> #> $vz.obs$datatype #> [1] "interval" #> #> #> $vz.pred #> $vz.pred$FUN #> [1] "pk.calc.vz" #> #> $vz.pred$values #> [1] FALSE TRUE #> #> $vz.pred$desc #> [1] "The terminal volume of distribution using predicted Clast" #> #> $vz.pred$formalsmap #> $vz.pred$formalsmap$cl #> [1] "cl.pred" #> #> #> $vz.pred$depends #> [1] "cl.pred" "lambda.z" #> #> $vz.pred$datatype #> [1] "interval" #> #> #> $vss.obs #> $vss.obs$FUN #> [1] "pk.calc.vss" #> #> $vss.obs$values #> [1] FALSE TRUE #> #> $vss.obs$desc #> [1] "The steady-state volume of distribution using observed Clast" #> #> $vss.obs$formalsmap #> $vss.obs$formalsmap$cl #> [1] "cl.obs" #> #> $vss.obs$formalsmap$mrt #> [1] "mrt.obs" #> #> #> $vss.obs$depends #> [1] "cl.obs" "mrt.obs" #> #> $vss.obs$datatype #> [1] "interval" #> #> #> $vss.pred #> $vss.pred$FUN #> [1] "pk.calc.vss" #> #> $vss.pred$values #> [1] FALSE TRUE #> #> $vss.pred$desc #> [1] "The steady-state volume of distribution using predicted Clast" #> #> $vss.pred$formalsmap #> $vss.pred$formalsmap$cl #> [1] "cl.pred" #> #> $vss.pred$formalsmap$mrt #> [1] "mrt.pred" #> #> #> $vss.pred$depends #> [1] "cl.pred" "mrt.pred" #> #> $vss.pred$datatype #> [1] "interval" #> #> #> $vss.iv.obs #> $vss.iv.obs$FUN #> [1] "pk.calc.vss" #> #> $vss.iv.obs$values #> [1] FALSE TRUE #> #> $vss.iv.obs$desc #> [1] "The steady-state volume of distribution with intravenous infusion using observed Clast" #> #> $vss.iv.obs$formalsmap #> $vss.iv.obs$formalsmap$cl #> [1] "cl.obs" #> #> $vss.iv.obs$formalsmap$mrt #> [1] "mrt.iv.obs" #> #> #> $vss.iv.obs$depends #> [1] "cl.obs" "mrt.iv.obs" #> #> $vss.iv.obs$datatype #> [1] "interval" #> #> #> $vss.iv.pred #> $vss.iv.pred$FUN #> [1] "pk.calc.vss" #> #> $vss.iv.pred$values #> [1] FALSE TRUE #> #> $vss.iv.pred$desc #> [1] "The steady-state volume of distribution with intravenous infusion using predicted Clast" #> #> $vss.iv.pred$formalsmap #> $vss.iv.pred$formalsmap$cl #> [1] "cl.pred" #> #> $vss.iv.pred$formalsmap$mrt #> [1] "mrt.iv.pred" #> #> #> $vss.iv.pred$depends #> [1] "cl.pred" "mrt.iv.pred" #> #> $vss.iv.pred$datatype #> [1] "interval" #> #> #> $vss.md.obs #> $vss.md.obs$FUN #> [1] "pk.calc.vss" #> #> $vss.md.obs$values #> [1] FALSE TRUE #> #> $vss.md.obs$desc #> [1] "The steady-state volume of distribution for nonlinear multiple-dose data using observed Clast" #> #> $vss.md.obs$formalsmap #> $vss.md.obs$formalsmap$cl #> [1] "cl.last" #> #> $vss.md.obs$formalsmap$mrt #> [1] "mrt.md.obs" #> #> #> $vss.md.obs$depends #> [1] "cl.last" "mrt.md.obs" #> #> $vss.md.obs$datatype #> [1] "interval" #> #> #> $vss.md.pred #> $vss.md.pred$FUN #> [1] "pk.calc.vss" #> #> $vss.md.pred$values #> [1] FALSE TRUE #> #> $vss.md.pred$desc #> [1] "The steady-state volume of distribution for nonlinear multiple-dose data using predicted Clast" #> #> $vss.md.pred$formalsmap #> $vss.md.pred$formalsmap$cl #> [1] "cl.last" #> #> $vss.md.pred$formalsmap$mrt #> [1] "mrt.md.pred" #> #> #> $vss.md.pred$depends #> [1] "cl.last" "mrt.md.pred" #> #> $vss.md.pred$datatype #> [1] "interval" #> #> #> $vd.obs #> $vd.obs$FUN #> [1] "pk.calc.vd" #> #> $vd.obs$values #> [1] FALSE TRUE #> #> $vd.obs$desc #> [1] "Apparent observed volume of distribution calculated with observed Clast" #> #> $vd.obs$formalsmap #> $vd.obs$formalsmap$aucinf #> [1] "aucinf.obs" #> #> #> $vd.obs$depends #> [1] "aucinf.obs" "lambda.z" #> #> $vd.obs$datatype #> [1] "interval" #> #> #> $vd.pred #> $vd.pred$FUN #> [1] "pk.calc.vd" #> #> $vd.pred$values #> [1] FALSE TRUE #> #> $vd.pred$desc #> [1] "Apparent observed volume of distribution calculated with predicted Clast" #> #> $vd.pred$formalsmap #> $vd.pred$formalsmap$aucinf #> [1] "aucinf.pred" #> #> #> $vd.pred$depends #> [1] "aucinf.pred" "lambda.z" #> #> $vd.pred$datatype #> [1] "interval" #> #> #> $thalf.eff.obs #> $thalf.eff.obs$FUN #> [1] "pk.calc.thalf.eff" #> #> $thalf.eff.obs$values #> [1] FALSE TRUE #> #> $thalf.eff.obs$desc #> [1] "The effective half-life (as determined from the MRTobs)" #> #> $thalf.eff.obs$formalsmap #> $thalf.eff.obs$formalsmap$mrt #> [1] "mrt.obs" #> #> #> $thalf.eff.obs$depends #> [1] "mrt.obs" #> #> $thalf.eff.obs$datatype #> [1] "interval" #> #> #> $thalf.eff.pred #> $thalf.eff.pred$FUN #> [1] "pk.calc.thalf.eff" #> #> $thalf.eff.pred$values #> [1] FALSE TRUE #> #> $thalf.eff.pred$desc #> [1] "The effective half-life (as determined from the MRTpred)" #> #> $thalf.eff.pred$formalsmap #> $thalf.eff.pred$formalsmap$mrt #> [1] "mrt.pred" #> #> #> $thalf.eff.pred$depends #> [1] "mrt.pred" #> #> $thalf.eff.pred$datatype #> [1] "interval" #> #> #> $thalf.eff.iv.obs #> $thalf.eff.iv.obs$FUN #> [1] "pk.calc.thalf.eff" #> #> $thalf.eff.iv.obs$values #> [1] FALSE TRUE #> #> $thalf.eff.iv.obs$desc #> [1] "The effective half-life (as determined from the intravenous MRTobs)" #> #> $thalf.eff.iv.obs$formalsmap #> $thalf.eff.iv.obs$formalsmap$mrt #> [1] "mrt.iv.obs" #> #> #> $thalf.eff.iv.obs$depends #> [1] "mrt.iv.obs" #> #> $thalf.eff.iv.obs$datatype #> [1] "interval" #> #> #> $thalf.eff.iv.pred #> $thalf.eff.iv.pred$FUN #> [1] "pk.calc.thalf.eff" #> #> $thalf.eff.iv.pred$values #> [1] FALSE TRUE #> #> $thalf.eff.iv.pred$desc #> [1] "The effective half-life (as determined from the intravenous MRTpred)" #> #> $thalf.eff.iv.pred$formalsmap #> $thalf.eff.iv.pred$formalsmap$mrt #> [1] "mrt.iv.pred" #> #> #> $thalf.eff.iv.pred$depends #> [1] "mrt.iv.pred" #> #> $thalf.eff.iv.pred$datatype #> [1] "interval" #> #> #> $kel.obs #> $kel.obs$FUN #> [1] "pk.calc.kel" #> #> $kel.obs$values #> [1] FALSE TRUE #> #> $kel.obs$desc #> [1] "Elimination rate (as calculated from the MRT with observed Clast)" #> #> $kel.obs$formalsmap #> $kel.obs$formalsmap$mrt #> [1] "mrt.obs" #> #> #> $kel.obs$depends #> [1] "mrt.obs" #> #> $kel.obs$datatype #> [1] "interval" #> #> #> $kel.pred #> $kel.pred$FUN #> [1] "pk.calc.kel" #> #> $kel.pred$values #> [1] FALSE TRUE #> #> $kel.pred$desc #> [1] "Elimination rate (as calculated from the MRT with predicted Clast)" #> #> $kel.pred$formalsmap #> $kel.pred$formalsmap$mrt #> [1] "mrt.pred" #> #> #> $kel.pred$depends #> [1] "mrt.pred" #> #> $kel.pred$datatype #> [1] "interval" #> #> #> $kel.iv.obs #> $kel.iv.obs$FUN #> [1] "pk.calc.kel" #> #> $kel.iv.obs$values #> [1] FALSE TRUE #> #> $kel.iv.obs$desc #> [1] "Elimination rate (as calculated from the intravenous MRTobs)" #> #> $kel.iv.obs$formalsmap #> $kel.iv.obs$formalsmap$mrt #> [1] "mrt.iv.obs" #> #> #> $kel.iv.obs$depends #> [1] "mrt.iv.obs" #> #> $kel.iv.obs$datatype #> [1] "interval" #> #> #> $kel.iv.pred #> $kel.iv.pred$FUN #> [1] "pk.calc.kel" #> #> $kel.iv.pred$values #> [1] FALSE TRUE #> #> $kel.iv.pred$desc #> [1] "Elimination rate (as calculated from the intravenous MRTpred)" #> #> $kel.iv.pred$formalsmap #> $kel.iv.pred$formalsmap$mrt #> [1] "mrt.iv.pred" #> #> #> $kel.iv.pred$depends #> [1] "mrt.iv.pred" #> #> $kel.iv.pred$datatype #> [1] "interval" #> #>