Calculate the AUC over an interval with interpolation and/or extrapolation of concentrations for the beginning and end of the interval.

pk.calc.aucint(
  conc,
  time,
  interval = NULL,
  start = NULL,
  end = NULL,
  clast = pk.calc.clast.obs(conc, time),
  lambda.z = NA,
  time.dose = NULL,
  route = "extravascular",
  duration.dose = 0,
  method = NULL,
  auc.type = "AUClast",
  conc.blq = NULL,
  conc.na = NULL,
  check = TRUE,
  ...,
  options = list()
)

pk.calc.aucint.last(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  ...,
  options = list()
)

pk.calc.aucint.all(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  ...,
  options = list()
)

pk.calc.aucint.inf.obs(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  lambda.z,
  clast.obs,
  ...,
  options = list()
)

pk.calc.aucint.inf.pred(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  lambda.z,
  clast.pred,
  ...,
  options = list()
)

Arguments

conc	Concentration measured
time	Time of concentration measurement (must be monotonically increasing and the same length as the concentration data)
interval	Numeric vector of two numbers for the start and end time of integration
start, end	The start and end of the interval (cannot be given if `interval` is given)
clast, clast.obs, clast.pred	The last concentration above the limit of quantification; this is used for AUCinf calculations. If provided as clast.obs (observed clast value, default), AUCinf is AUCinf,obs. If provided as clast.pred, AUCinf is AUCinf,pred.
lambda.z	The elimination rate (in units of inverse time) for extrapolation
time.dose, route, duration.dose	The time of doses, route of administration, and duration of dose used with interpolation and extrapolation of concentration data (see `interp.extrap.conc.dose`). If `NULL`, `interp.extrap.conc` will be used instead (assuming that no doses affecting concentrations are in the interval).
method	The method for integration (either 'lin up/log down' or 'linear')
auc.type	The type of AUC to compute. Choices are 'AUCinf', 'AUClast', and 'AUCall'.
conc.blq	How to handle BLQ values in between the first and last above LOQ concentrations. (See `clean.conc.blq` for usage instructions.)
conc.na	How to handle missing concentration values. (See `clean.conc.na` for usage instructions.)
check	Run `check.conc.time`, `clean.conc.blq`, and `clean.conc.na`?
...	Additional arguments passed to `pk.calc.auxc` and `interp.extrap.conc`
options	List of changes to the default `PKNCA.options` for calculations.

Functions

pk.calc.aucint.last: Interpolate or extrapolate concentrations for AUClast
pk.calc.aucint.all: Interpolate or extrapolate concentrations for AUCall
pk.calc.aucint.inf.obs: Interpolate or extrapolate concentrations for AUCinf.obs
pk.calc.aucint.inf.pred: Interpolate or extrapolate concentrations for AUCinf.pred

Calculate the AUC over an interval with interpolation and/or extrapolation of concentrations for the beginning and end of the interval.

Arguments

Functions

See also