Event objects for simulating PK and other interventions

Source: R/events.R

An event object specifies dosing or other interventions that get implemented during simulation. Event objects do similar things as data_set, but simpler and quicker.

ev(x, ...)

# S4 method for mrgmod
ev(x, object = NULL, ...)

# S4 method for missing
ev(
  time = 0,
  amt = 0,
  evid = 1,
  cmt = 1,
  ID = numeric(0),
  replicate = TRUE,
  until = NULL,
  tinf = NULL,
  realize_addl = FALSE,
  ...
)

# S4 method for ev
ev(x, realize_addl = FALSE, ...)

Arguments

x

a model object
...

other items to be incorporated into the event object; see details
object

passed to show
time

event time
amt

dose amount
evid

event ID
cmt

compartment
ID

subject ID
replicate

logical; if TRUE, events will be replicated for each individual in ID
until

the expected maximum observation time for this regimen
tinf

infusion time; if greater than zero, then the rate item will be derived as amt/tinf
realize_addl

if FALSE (default), no change to addl doses. If TRUE, addl doses are made explicit with realize_addl

Value

events object

Details

  • Required items in events objects include time, amt, evid and cmt.

  • If not supplied, evid is assumed to be 1.

  • If not supplied, cmt is assumed to be 1.

  • If not supplied, time is assumed to be 0.

  • If amt is not supplied, an error will be generated.

  • If total is supplied, then addl will be set to total - 1.

  • Other items can include ii, ss, and addl (see data_set for details on all of these items).

  • ID may be specified as a vector.

  • If replicate is TRUE (default), then the events regimen is replicated for each ID; otherwise, the number of event rows must match the number of IDs entered

See also

ev_rep, ev_days, ev_repeat, ev_assign, ev_seq, mutate.ev, as.ev, ev_methods

Examples

mod <- mrgsolve::house()

mod <- mod %>% ev(amt=1000, time=0, cmt=1)

loading <- ev(time=0, cmt=1, amt=1000)

maint <- ev(time=12, cmt=1, amt=500, ii=12, addl=10)

c(loading, maint)
#> Events:
#>   time  amt cmt evid ii addl
#> 1    0 1000   1    1  0    0
#> 2   12  500   1    1 12   10

loading$time
#> [1] 0