Exclude NCA parameters based on examining the parameter set.

Exclude NCA parameters based on examining the parameter set.

exclude_nca_span.ratio(min.span.ratio)

exclude_nca_max.aucinf.pext(max.aucinf.pext)

exclude_nca_min.hl.r.squared(min.hl.r.squared)

Arguments

min.span.ratio	The minimum acceptable span ratio (uses PKNCA.options("min.span.ratio") if not provided).
max.aucinf.pext	The maximum acceptable percent AUC extrapolation (uses PKNCA.options("max.aucinf.pext") if not provided).
min.hl.r.squared	The minimum acceptable r-squared value for half-life (uses PKNCA.options("min.hl.r.squared") if not provided).

Functions

• exclude_nca_span.ratio: Exclude based on span.ratio

• exclude_nca_max.aucinf.pext: Exclude based on AUC percent extrapolated (both observed and predicted)

• exclude_nca_min.hl.r.squared: Exclude based on half-life r-squared

See also

Other Result exclusions: exclude()

Examples

my_conc <- PKNCAconc(data.frame(conc=1.1^(3:0),
                                time=0:3,
                                subject=1),
                     conc~time|subject)
my_data <- PKNCAdata(my_conc,
                     intervals=data.frame(start=0, end=Inf,
                                          aucinf.obs=TRUE,
                                          aucpext.obs=TRUE))
my_result <- pk.nca(my_data)
#> No dose information provided, calculations requiring dose will return NA.
my_result_excluded <- exclude(my_result,
                              FUN=exclude_nca_max.aucinf.pext())
as.data.frame(my_result_excluded)
#>    start end subject            PPTESTCD     PPORRES
#> 1      0 Inf       1             auclast  3.47287143
#> 2      0 Inf       1                tmax  0.00000000
#> 3      0 Inf       1               tlast  3.00000000
#> 4      0 Inf       1           clast.obs  1.00000000
#> 5      0 Inf       1            lambda.z  0.09531018
#> 6      0 Inf       1           r.squared  1.00000000
#> 7      0 Inf       1       adj.r.squared  1.00000000
#> 8      0 Inf       1 lambda.z.time.first  1.00000000
#> 9      0 Inf       1   lambda.z.n.points  3.00000000
#> 10     0 Inf       1          clast.pred  1.00000000
#> 11     0 Inf       1           half.life  7.27254090
#> 12     0 Inf       1          span.ratio  0.27500705
#> 13     0 Inf       1          aucinf.obs 13.96493011
#> 14     0 Inf       1         aucpext.obs 75.13148009
#>                          exclude
#> 1                           <NA>
#> 2                           <NA>
#> 3                           <NA>
#> 4                           <NA>
#> 5                           <NA>
#> 6                           <NA>
#> 7                           <NA>
#> 8                           <NA>
#> 9                           <NA>
#> 10                          <NA>
#> 11                          <NA>
#> 12                          <NA>
#> 13 AUC percent extrapolated > 20
#> 14 AUC percent extrapolated > 20