modlib: Pharmacokinetic models
passed to update
an object of class packmod
See modlib_details for more detailed descriptions of
parameters and compartments.
The pk1cmt model is parameterized in terms of CL, VC,
KA1 and KA2 and uses compartments EV1,
EV2, and CENT. The pk2cmt model adds a PERIPH
compartment and parameters Q and VP to that of the
one-compartment model. Likewise, the three-compartment model (pk3cmt)
adds PERIPH2 and parameters Q2 and VP2 to
that of the two-compartment models. All pk models also have parameters
VMAX (defaulting to zero, no non-linear clearance) and KM.
All pk models have two extravascular dosing compartments and potential for linear and nonlinear clearance.
pk1cmt: one compartment pk model using ODEs
pk2cmt: two compartment pk model using ODEs
pk3cmt: three compartment pk model using ODEs
pk1: one compartment pk model in closed-form
pk2: two compartment pk model in closed-form
popex: a simple population pk model