modlib: Pharmacokinetic / pharmacodynamic models
See modlib_details for more detailed descriptions of
parameters and compartments.
All PK/PD models include 2-compartment PK model with absorption from
2 extravascular compartments and linear + nonlinear clearance. The
PK models are parameterized with CL, VC, Q,
VMAX, KM, KA1 and KA2 and implement
compartments EV1, EV2, CENT, PERIPH .
The indirect response models have compartment RESP and the emax
model has output variable RESP. PD parameters include KIN,
KOUT, IC50, EC50, IMAX, EMAX, E0,
and n.
Also, once the model is loaded, use see method for
mrgmod to view the model code.
irm1 inhibition of response production
irm2 inhibition of response loss
irm3 stimulation of response production
irm4 stimulation of response loss
pd_effect effect compartment model
emax sigmoid emax model